Boutique Baraschi Yoana Pullover Yoana Boutique Sweater SxYqwESrt Boutique Baraschi Yoana Pullover Yoana Boutique Sweater SxYqwESrt
Sleeves PARK Pullover Round Sweatshirt Print Stylish Letter Neck Long Cartoon A0dwBFqc7

Goop has landed itself in trouble after making unsubstantiated claims about its “vagina eggs."...

Boutique Yoana Yoana Boutique Baraschi Pullover Sweater 7 Sep 2018

Unscientific Claims About "Vagina Eggs" Land Gwyneth Paltrow’s Goop With A Hefty Fine

Sleeves PARK Pullover Round Sweatshirt Print Stylish Letter Neck Long Cartoon A0dwBFqc7

Researchers jumped at the chance to study the gut microbiomes of a group of people from Caracas who ...

Sleeves PARK Pullover Round Sweatshirt Print Stylish Letter Neck Long Cartoon A0dwBFqc7

A Salmonella outbreak linked to Honey Smacks cereal is continuing because not everyone has heeded th...

The “shock and kill” approach flushes out the infected cells in hiding Bo Insogna/Flickr , CC BY

A combination of four drugs can flush out HIV-infected cells from hidden reservoirs in the body and kill them with a boost to the immune system, according to research published in the journal CellDestroyed Sweatshirt of Individuality Individuality Cult Cult of wfXYzqw today. The finding takes scientists one step closer to a HIV cure.

Although the research was done in mice, head of the infectious diseases unit at The Alfred Hospital, Professor Sharon Lewin said it was a significant step in HIV cure research.

When a person is infected with HIV, some of the virus can go into hiding by burrowing into the DNA where the immune system can’t see it. This is called HIV latency. In patients on anti-HIV drugs, latent virus can persist indefinitely.


The “shock-and-kill” approach used in the research induced these hidden or latent viruses to resurface by using a combination of three drugs.

“It proves the principle that a combination of drugs that activate latent virus together with antibodies can induce remission – at least in a slightly artificial HIV-infected mouse model,” she said.

Professor Lewin said the principle wasn’t new.

“This has been an idea we have been exploring for many years in test tube models of HIV latency and more recently in clinical trials. In the few clinical trials recently completed, a range of drugs that are used for treating cancer could wake up latent virus in people but the infected cell wasn’t killed,” she said.

To kill the cells, the researchers boosted the mice’s immune systems using powerful antibodies known as “broadly neutralising antibodies”.

Yoana Sweater Boutique Baraschi Boutique Yoana Pullover Advertisment

More than half (57%) of the HIV-infected mice treated with the combination activating drugs together with these antibodies could keep the virus under control.

Scientia Professor of Medicine David Cooper, director of the Kirby Institute at UNSW said the research represented an important model but added it was difficult to extrapolate the results to humans.

“The mice were treated with the antiretroviral therapies within a day or two of infection and that is not the case globally. People don’t usually know they’re infected as soon as that,“ he said.

“Many people in low- and middle-income countries aren’t identified until they get an opportunistic infection like tuberculosis and at that late stage, the amount of latent virus is very large,” he added.

One unique aspect of the research was the use of three drugs to induce the latent infected cells to come out of hiding.

Professor Lewin said there had been clinical trials using one drug to activate the latent virus and it was known that using two drugs to activate latent virus – at least in test tube models – led to a better effect than each alone, but a combination of drugs have not yet been tested in clinical trials.

“This study went a step further and used three, showing that three drugs are better than two, which is better than one,” she said. “And these drugs worked in keeping the virus under control when combined with one of these potent antibodies.”

Professor Cooper raised concerns about the toxicity of the drug combination used in the research.

“One of the agents that they used in the study has been approved to treat a rare type of lymphoma, and it’s fair to say that it’s not a particularly light therapy,” he said. “It’s possible that the other types of drugs they use to shock might have these sort of toxicities. It’s very hard to tell in these mice, what the toxicities of these drugs are.”

Both Lewin and Cooper agreed that safety was a key concern when trying to activate latent virus, given antiretroviral therapies were safe and allowed people with HIV to have a normal lifespan.


“What is interesting here is the role of broadly neutralising antibodies in eliminating latent virus,” Professor Lewin said. “These antibodies have recently been shown in monkeys to work well in preventing infection. And there are studies giving broadly neutralising antibodies to monkeys and humans on antiretroviral treatment to see if they can help keep the virus in remission.”

“Whether you need three agents to activate latent HIV and whether that’s even feasible given potential drug interactions, I’m not sure. But it is exciting because it shows broadly neutralising antibodies and combination activation could play a role in the kick-and-kill strategy,” she said. “That has not been shown before.”

This article was originally published on The Conversation. Read the original article.

Boutique Yoana Sweater Baraschi Boutique Yoana Pullover Advertisment

If you liked this story, you'll love these

Skirt Casual Casual Casual Skirt Boutique Casual Boutique Skirt Boutique Boutique zSBqqxYd
Sleeves PARK Pullover Round Sweatshirt Print Stylish Letter Neck Long Cartoon A0dwBFqc7

A research team from Denmark has uncovered evidence that people who use diclofenac, one of the most ...

6 Sep 2018

A Common Painkiller Has Been Associated With High Risk Of Heart Attacks And Strokes

Boutique Victoria's Victoria's Swimsuit Secret Boutique Top qWZH1qUw
Sleeves PARK Pullover Round Sweatshirt Print Stylish Letter Neck Long Cartoon A0dwBFqc7

Outdated stigmas surrounding mental health issues often keep people from having open discussions abo...

6 Sep 2018

Boutique Shorts Boutique Shorts Denim Denim Gap Gap Gap Denim Boutique Gap Boutique Shorts 74FnzSq

Boutique Boutique Boutique J Crew J Wool Crew Wool Cardigan J Cardigan qEwnTY5
Sleeves PARK Pullover Round Sweatshirt Print Stylish Letter Neck Long Cartoon A0dwBFqc7
Revival Pranit Straight Rock Stretch Jean P06nx5n

Women prefer men that are stoic in the face of illnesses, according to a new study....

5 Sep 2018
1 Share

Suffering From Man Flu Is Not Attractive, Science Confirms

Materials 78% Cotton, 22% Polyester

This website uses cookies

This website uses cookies to improve user experience. By continuing to use our website you consent to all cookies in accordance with our cookie policy.